Chronic Hypertension During the First Trimester of Pregnancy: What is New About the Use of Angiotensin- Converting Enzyme Inhibitors?

Cardiovascular diseases are a major cause of maternal mortality and morbidity worldwide, including developed countries. The first-line drug to treat hypertension in pregnant women is methyldopa, which is an α2-adrenergic agent that has shown maternal and fetal safety and efficacy. However, methyldopa is not effective in all cases, and sometimes it is important to consider other pharmacological agents.

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