Iris Publishers_World Journal of Gynecology & Womens Health

An Evaluation of Ovarian Response and Pregnancy Rates with the Use of Growth Hormone as an Adjunct to IVF in Women who are Poor Responders to Standard IVF Stimulation Protocols

Background: Women who fail to respond adequately to standard ovarian stimulation protocols pose a significant treatment challenge. Research has been conducted in order to identify risk factors and causes of poor ovarian response and has attempted to identify new strategies which may improve the response to ovarian stimulation with standard IVF protocols. Growth hormone (GH) supplementation is one of these strategies proposed as a management option for poor IVF responders. GH is needed for growth and development but is also involved in the modulation of both male and female fertility through both gonadotrophin-dependent and gonadotrophin-independent actions. Some studies have shown that the supplementation of GH as an adjunct to ovarian stimulation for poor ovarian responders improves oocyte quality and increases pregnancy rates; while other studies has shown it to have no significant effect.

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